Patch testing with fragrance mix II: results of the IVDK 2005-2008

作者：Krautheim Andrea^*; Uter Wolfgang; Frosch Peter; Schnuch Axel; Geier Johannes

来源：Contact Dermatitis, 2010, 63(5): 262-269.

DOI：10.1111/j.1600-0536.2010.01753.x

• citral
• citronellol
• coumarin
• farnesol
• fragrance allergy
• fragrance mix II
• hexyl cinnamal
• hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC)
• patch test

Background: The fragrance mix (FM I), established in 1977, detects the majority, but not all cases of contact allergy to fragrances. Based on European research 2002/2003, fragrance mix II (FM II) was developed to supplement FM I. In 2005, the German Contact Dermatitis Research Group (DKG) added FM II to their baseline series.
Objectives: To evaluate reactions to FM II and its constituents in routine patch testing.
Methods: Retrospective data analysis of the Information Network of Departments of Dermatology (IVDK), 2005-2008, of patch test results with FM II and its constituents.
Results: A total of 35 633 patients were patch tested with FM II as part of the DKG baseline series. Of these, 1742 (4.9%) reacted positively. Concomitant reactions to FM I were observed in 41.9% of the patients reacting to FM II. In 367 FM II-positive patients, a full breakdown test of the mix was performed. Of these, 47.7% reacted to hydroxyisohexyl 3-cyclohexene carboxaldehyde, 16.1% to citral, 11.4% to farnesol, 3.8% to hexyl cinnamal, 2.7% to coumarin, and 2.5% to citronellol.
Conclusions: FM II is an important screening and diagnostic tool to detect fragrance allergy. Hydroxyisohexyl 3-cyclohexene carboxaldehyde is the most important fragrance allergen in FM II.

• 出版日期2010