Aberrant Expression of Multiple T Antigens: CD4, CD5, and CD8 on Diffuse Large B-cell Lymphoma

作者：Sangle Nikhil A^*; Miles Rodney R; Kelley Todd W; Perkins Sherrie L

来源：Applied Immunohistochemistry & Molecular Morphology, 2014, 22(10): e45-e48.

DOI：10.1097/PAI.0b013e31829cc54c

• aberrant
• T antigens
• DLBCL

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Aberrant expression of T antigens (exclusive of CD5) in DLBCL has been described in the literature; however, coexpression of 2 or more T antigens is rare. We report a case with a well-established diagnosis of DLBCL, coexpressing 3 T-cell antigens, CD4, CD5, and CD8. Although the clinical significance of T antigen coexpression in DLBCL is unclear, it is important to be aware of such phenotypic plasticity to ensure accurate diagnoses are made. The expression of multiple T-cell antigens may introduce diagnostic confusion and make subclassification of a lymphoma using World Health Organization criteria difficult.

• 出版日期2014-12