A New Furostanol Saponin from Asparagus cochinchinensis

作者：Shen Yang; Xu Cong Li; Xuan Wei Dong; Li Hui Liang; Liu Run Hui; Xu Xi Ke; Chen Hai Sheng^*

来源：Archives of Pharmacal Research, 2011, 34(10): 1587-1591.

DOI：10.1007/s12272-011-1001-7

• Asparagus cochinchinensis
• Furostanol glycosides
• Cytotoxicity

A new furostanol saponin, (25S)-26-O-beta-D-glucopyranosyl-5 beta-furost-20(22)-en-3 beta, 15 beta,26-triol-3-O-[alpha-L-rhamnopyranosyl-(1-4)]-beta-D-glucopyranoside, namely, aspacochioside D (1) were isolated from Asparagus cochinchinensis (Lour.) Merr, along with three known saponins, aspacochioside C (2), (25S)-5 beta-spirostan-3 beta-yl-O-[O-alpha-L-rhamnopyranosyl-(1-4)]-beta-D-glucopyranoside (3), and pseudoprotoneodioscin (4). The structure of 1 was elucidated on the basis of chemical reactions and spectral analysis (IR, GC, ESI-MS, H-1-NMR, C-13-NMR, DEPT, HMBC, HMQC and NOESY). The antiproliferative effects of 1-4 were evaluated in a cytotoxicity assay against the human tumor cell line, A549. Compound 2 (Aspacochioside C) exhibited moderate cytotoxicity against A-549, with an IC50 value of 3.87 mu g/mL.

• 出版日期2011-10
• 单位中国人民解放军第二军医大学