Development of drug delivery systems for taxanes using ionic gelation of carboxyacyl derivatives of chitosan

作者：Skorik Yury A^*; Golyshev Anton A; Kritchenkov Andreii S; Gasilova Ekaterina R; Poshina Daria N; Sivaram Amal J; Jayakumar Rangasamy

来源：Carbohydrate Polymers, 2017, 162: 49-55.

DOI：10.1016/j.carbpol.2017.01.025

• Succinyl-chitosan
• Glutaryl-chitosan
• Drug delivery
• Ionic gelation
• Paclitaxel
• Docetaxel

Nanoparticles of two chitosan derivatives - N-succinyl-chitosan (SC) and N-glutaryl-chitosan (GC) - were developed as passive transport systems for taxanes (paclitaxel and docetaxel) using an ionic gelation technique with sodium tripolyphosphate. These nanoparticles had an apparent hydrodynamic diameter of 300-350 nm, a zeta-potential of 25-31 mV, an encapsulation efficiency of 21-26%, and a drug loading efficiency of 6-13%. DLS and SLS analysis shows that the nanoparticles have a unimodal size distribution and spherical form. Drug release kinetics of the taxane-loaded nanoparticles demonstrates that more than 50% of the loaded taxane could be released upon the degradation of the nanoparticles after targeted delivery. The drug-loaded SC and GC nanoparticles exhibit high cytotoxicity towards AGS cancer cell lines and their antitumor activity is consequently enhanced when compared with free taxanes.

• 出版日期2017-4-15
• 单位河北医科大学