Association of serum uric acid with lupus nephritis in systemic lupus erythematosus

作者：Yang, Zaixing; Liang, Yan; Xi, Weihua; Zhu, Ye; Li, Chang; Zhong, Renqian^*

来源：Rheumatology International, 2011, 31(6): 743-748.

DOI：10.1007/s00296-010-1373-x

• Lupus nephritis
• Systemic lupus erythematosus
• Uric acid

The aim of the present study is to assess the association of elevated serum uric acid (UA) with lupus nephritis (LN) in systemic lupus erythematosus (SLE) patients. A total of 130 SLE patients were recruited, of whom 73 patients developed LN. Blood samples were obtained for determination of uric acid, complement 3 (C3), C-reactive protein (CRP) and some autoantibodies including anti-double-stranded DNA, -Smith, -SSA, -SSB, -U1RNP, SCL-70, and -Jo-1 antibodies. Correlations of UA with LN were assessed. UA was an independent risk factor for LN [odds ratio (95% CI): 1.01 (1.005-1.014); P = 0.0000]. The best cut-off value for UA using the ROC curve was 330 mu mol/L (sensitivity 78.1% and specificity 75.4%) and the area under the ROC curve was 0.803 +/- A 0.039 (95% CI: 0.727-0.878, P = 0.000). Spearman's correlation coefficient analysis showed negative association of UA with C3 in SLE patients with LN (r = -0.356, P = 0.002), but no association in those without LN. No correlations were found between UA and age, SLEDAI, CRP, IgG, IgM or IgA. Furthermore, analysis of covariance demonstrated that anti-Sm (beta = -0.218, P = 0.004) and -U1RNP (beta = 0.177, P = 0.008) autoantibodies were independent determinants of serum UA. The UA level is independently associated with the development of LN in SLE patients.

• 出版日期2011-6
• 单位中国人民解放军第二军医大学; 天津市中医药研究院附属医院