Mechanism of photocatalytic oxidation of guanine by BiOBr under UV irradiation

作者：Hou, Haobo; Wang, Xiaoxing; Chen, Chuncheng^*; Johnson, David M.; Fang, Yanfen; Huang, Yingping

来源：Catalysis Communications, 2014, 48: 65-68.

DOI：10.1016/j.catcom.2014.01.023

• Guanine base
• Oxidative damage
• Photocatalysis
• Mechanism

This article analyzes the mechanism details of guanine photocatalytic oxidation on the surface of BiOBr nanopartides under UV irradiation. The reaction of O-2(.)- with radical species, generated from primary oxidation of guanine by hole, is proposed to be the dominant cause of guanine damage. The present work demonstrates that Bi0Br photocatalysis provided good model to investigate the reaction of substrate radical with the in situ formed O-2(.)-. It also implicates that the frequently-used biomarker for DNA damage 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) may be ineffective in the situation that damage is caused by O-2(.-).

• 出版日期2014-3-10
• 单位武汉大学; 三峡大学