An optimal initial tension for rat basilar artery in wire myography

作者：Xiao Xue; Ping Na na; Li Sen; Cao Lei^*; Cao Yong xia

来源：Microvascular Research, 2015, 97: 156-158.

DOI：10.1016/j.mvr.2014.11.001

• Basilar artery
• Normalization procedure
• Optimal initial tension
• Wire myograph
• Rat

Aims: The aim of the present study was to determine the optimal initial tension for the rat basilar artery when using wire myography.
Methods: Rat basilar arteries were mounted in myograph baths. A normalization procedure was performed. K+-rich (60 mM) buffer solution-induced tension was measured in different initial tensions.
Results: The initial tension of the basilar artery increased from 0.47 to 2.68 mN/mm. Contractile tension was also elevated along with the initial tension. When the initial tension reached 1.63 mN/mm, K+-induced contractile tension of basilar artery achieved its maximum. Thereafter, contractile tension declined as initial tension increased. The duration of equilibration time did not affect K+-induced contractile tension.
Conclusion: The optimal initial tension is 1.63 +/- 0.01 mN/mm in rat basilar arteries when using wire myography.

• 出版日期2015-1
• 单位西安交通大学