Differential Impact of Risk Factors for Women and Men on the Risk of Major Depressive Disorder

作者：Stegenga Bauke T; King Michael; Grobbee Diederick E; Torres Gonzalez Francisco; Svab Igor; Maaroos Heidi Ingrid; Xavier Miguel; Saldivia Sandra; Bottomley Christian; Nazareth Irwin; Geerlings Mirjam I^*

来源：Annals of Epidemiology, 2012, 22(6): 388-396.

DOI：10.1016/j.annepidem.2012.04.011

• Depression
• Sex
• Epidemiology
• Interaction Contrast
• Cohort

PURPOSE: Our aim is to examine which risk factors have a greater impact in women than in men on the risk of major depressive disorder (MDD) and whether factors differ between a possible recurrent MDD and a first onset of MDD. %26lt;br%26gt;METHODS: Prospective cohort study of general practice attendees in seven countries, who were followed up at 6 and 12 months (predictD). Absolute risk differences (interaction contrast) across sex for onset of DSM-IV MDD after 6 or 12 months of follow-up were estimated for 35 risk factors from 7101 participants without MDD at baseline. %26lt;br%26gt;RESULTS: A total of 599 participants (80% female) had an onset of MDD at 6 or 12 months. Most risk factors had a greater impact in women than in men on the risk of MDD and were not restricted to a specific class of risk factors. After we stratified for a history of depressive symptoms, we found that the impact of risk factors across sex was generally stronger on possible recurrent MDD than on a first onset of MDD. %26lt;br%26gt;CONCLUSIONS: Our findings may partly account for the observed difference in incidence of MDD between men and women. Ann Epidemiol 2012;22:388-396.

• 出版日期2012-6