Aerosol deposition doses in the human respiratory tree of electronic cigarette smokers

作者：Manigrasso Maurizio^*; Buonanno Giorgio; Fuoco Fernanda Carmen; Stabile Luca; Avino Pasquale

来源：Environmental Pollution, 2015, 196: 257-267.

DOI：10.1016/j.envpol.2014.10.013

• E-cigarette
• Aerosol
• Human respiratory system
• Deposition dose
• Lobar bronchi
• MPPD

Aerosols from eight e-cigarettes at different nicotine levels and flavoring were characterized as particle number size distributions in the range 5.6-560 nm by FMPS and CPC. Results were used to provide dosimetry estimates applying the MMPD model.
Particle number concentrations varied between 3.26 x 10(9) and 4.09 x 10(9) part cm(-3) for e-liquids without nicotine and between 5.08 x 10(9) and 5.29 x 10(9) part cm(-3) for e-liquids with nicotine. No flavor effects were detected on particle concentration data. Particle size distributions were unimodal with modes between 107-165 nm and 165-255 nm, for number and volume metrics, respectively.
Averagely, 6.25 x 10(10) particles were deposited in respiratory tree after a single puff. Highest deposition densities and mean layer thickness of e-cigarette liquid on the lung epithelium were estimated at lobar bronchi.
Our study shows that e-cigarette aerosol is source of high particle dose in respiratory system, from 23% to 35% of the daily dose of a no-smoking individual.

• 出版日期2015-1