A Facile and Efficient Approach to the Synthesis of 2,6-Diacetylpyridine

作者:Xie Guangyong*; Ai Haitao; Lei Lu; Zhang Dongfang
来源:Journal of the Chemical Society of Pakistan, 2009, 31(4): 674-676.

摘要

2,6-Diacetylpyridine was synthesized via esterification by using pyridine-2,6-dicarboxylic acid as precursor and successive Claisen condensation promoted by sodium for the first time. Compared with traditional sodium ethylate promoted Claisen condensation, the yield of 2,6-diacetylpyridine was improved greatly, and the procedures were simpler and convenient.