A reduction in both visceral and subcutaneous fats contributes to increased adiponectin by lifestyle intervention in the Diabetes Prevention Program

作者：Zhang, Chao; Luo, Hao; Gao, Feng; Zhang, Chun-Ting; Zhang, Ren^*

来源：Acta Diabetologica, 2015, 52(3): 625-628.

DOI：10.1007/s00592-014-0655-2

• Adiponectin
• Subcutaneous adipose tissue
• Visceral adipose tissue

Adiponectin, an insulin-sensitizing adipokine, confers protection against type 2 diabetes. Although adiponectin is secreted exclusively from fat, contributions of visceral adipose tissue (VAT) versus subcutaneous adipose tissue (SAT) to adiponectin levels have not been fully understood. We aimed to examine correlations between changes in VAT and SAT volumes and changes in adiponectin levels.
Here, we have investigated the correlations between Delta VAT and Delta SAT with Delta adiponectin in participants of the Diabetes Prevention Program, a clinical trial investigating the effects of lifestyle changes and metformin versus placebo on the rate of developing type 2 diabetes. Data on VAT and SAT volumes, measured by computed tomography, and on adiponectin levels at both baseline and 1-year follow-up were available in 321 men and 626 women.
In men, Delta adiponectin was highly significantly correlated with both Delta SAT (r (s) = -0.329) and Delta VAT (r (s) = -0.413). Likewise, in women, Delta adiponectin was correlated with both Delta SAT (r (s) = -0.294) and Delta VAT (r (s) = -0.348). In the lifestyle arm, Delta adiponectin remained highly significantly correlated with Delta SAT and Delta VAT in men (r (s) = -0.399 and r (s) = -0.460, respectively), and in women (r (s) = -0.372 and r (s) = -0.396, respectively), with P < 0.001 for all above correlations.
We conclude that for both men and women, adiponectin changes are highly significantly correlated with changes in both SAT and VAT and that exercise- and weight-loss-induced reduction in both SAT and VAT contributes to the increased adiponectin.

• 出版日期2015-6
• 单位天津大学