A novel prognostic index-neutrophil times gamma-glutamyl transpeptidase to lymphocyte ratio (N gamma LR) predicts outcome for patients with hepatocellular carcinoma

作者：Li, Jun; Liao, Yan; Suo, Liya; Zhu, Pengpeng; Chen, Xinhuang; Dang, Wei; Liao, Minjun; Qin, Liling; Liao, Weijia^*

来源：Scientific Reports, 2017, 7(1): 9229.

DOI：10.1038/s41598-017-09696-y

• LIVER-TRANSPLANTATION
• STAGING-SYSTEM
• RECURRENCE
• AMINOTRANSFERASE
• BIOMARKERS
• SIGNATURE
• RESECTION
• RISK

Clinical outcomes of patients with hepatocellular carcinoma (HCC) are highly variable. This study aims to identify and validate a simple, readily available, and objective prognostic index for the management of HCC. Data from 724 HCC patients undergoing curative resection were evaluated and randomly divided into two cohorts for building and validating the prognostic index. A best model, N gamma LR = (neutrophil count [10(9)/L] x gamma-glutamyl transpeptidase [U/L])/(lymphocyte count [109/L] x U/L), was selected. An optimal cut-off value of 103.6 for N gamma LR stratified patients into high N gamma LR (>103.6) and low N gamma LR (<= 103.6) groups. N gamma LR > 103.6 was closely associated with HCC malignant characteristics. Elevated N.LR predicted a worse overall survival (OS) and progression-free survival (PFS) for HCC patients and remained an independent predictor for both types of survival. Moreover, early recurrence rates in patients with N gamma LR > 103.6 were higher than that in patients with N gamma LR <= 103.6 (P < 0.0001). N gamma LR was an important independent predictor of survival for HCC patients and might be a new promising method to identify patients at different risks of early recurrence and survival after curative resection.

• 出版日期2017-8-23
• 单位广西医科大学; 桂林医学院