Ajmaline attenuates electrocardiogram characteristics of inferolateral early repolarization

作者：Roten Laurent^*; Derval Nicolas; Sacher Frederic; Pascale Patrizio; Wilton Stephen B; Scherr Daniel; Shah Ashok; Pedersen Michala E F; Jadidi Amir S; Miyazaki Shinsuke; Knecht Sebastien; Hocini Meleze; Jais Pierre; Haissaguerre Michel

来源：Heart Rhythm, 2012, 9(2): 232-239.

DOI：10.1016/j.hrthm.2011.09.013

• Early repolarization
• Brugada syndrome
• J wave
• Ajmaline
• Antiarrhythmic drugs
• Electrocardiogram

BACKGROUND J waves are the hallmark of both inferolateral early repolarization (ER) and Brugada syndrome. While ajmaline, a class 1a antiarrhythmic drug, accentuates the J wave in Brugada syndrome, its effect on ER is unreported.
OBJECTIVE To describe the effect of ajmaline on the electrocardiogram in ER
METHODS We analyzed electrocardiograms before and after the administration of intravenous ajmaline (1 mg/kg) in 31 patients with ER, 21 patients with Brugada type 1 electrocardiogram (Br), and 22 controls. ER was defined as J-point elevation of >= 1 mm with QRS slurring or notching in >= 2 inferolateral leads (I, aVL, II, III, aVF, V4-V6).
RESULTS Ajmaline decreased mean J-wave amplitude in the ER group from 0.2 +/- 0.15 mV at baseline to 0.08 +/- 0.09 mV (P < .001). The QRS width prolonged significantly in all 3 groups, but the prolongation was significantly less in the ER group (+21 ms) than in the Br group (+36 ms; P < .001) or controls (+28 ms; P = .010). Decrease in mean inferolateral R-wave amplitude was similar in all the groups (ER group -0.14 mV; Br group -0.11 mV; controls -0.13 mV; P = ns), but mean inferolateral S-wave amplitude increased significantly less in the ER group (ER group +0.14 mV; Br group +16 mV; controls +0.20 mV; P < .001).
CONCLUSIONS: Ajmaline significantly decreases the J-wave amplitude in ER and prolongs the QRS width significantly less than in patients with Br. This indicates a different pathogenesis for both disorders. The altered terminal QRS vector probably is responsible for the decrease in the J-wave amplitude in ER, although a specific effect of ajmaline on J waves cannot be excluded.

• 出版日期2012-2
• 单位河南工业大学