Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae

作者：Doernberg Sarah^*; Schaaf Bernhard; Dalhoff Klaus; Leng Lin; Beitin Anna; Quagliarello Vincent; Bucala Richard

来源：Cytokine, 2011, 53(3): 292-294.

DOI：10.1016/j.cyto.2010.12.010

• Macrophage migration inhibitory factor
• Cytokine
• Polymorphism
• Meningitis
• Inflammation

Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.

• 出版日期2011-3