Are Selective Serotonin Reuptake Inhibitors Associated With Greater Apathy in Parkinson's Disease?

作者：Zahodne Laura B; Bernal Pacheco Oscar; Bowers Dawn; Ward Herbert; Oyama Genko; Limotai Natlada; Velez Lago Frances; Rodriguez Ramon L; Malaty Irene; McFarland Nikolaus R; Okun Michael S^*

来源：Journal of Neuropsychiatry and Clinical Neurosciences, 2012, 24(3): 326-330.

DOI：10.1176/appi.neuropsych.11090210

Apathy is a common neuropsychiatric feature of Parkinson's disease (PD), but little is known of relationships between apathy and specific medications in PD. Following a retrospective database and chart review of 181 Parkinson's patients, relationships between Apathy Scale scores and use of psychotropic and antiparkinsonian medications were examined with multiple regression. Controlling for age, sex, education, and depression, the use of selective serotonin reuptake inhibitors (SSRIs), but not other antidepressants, was associated with greater apathy. Use of monoamine oxidase B inhibitors was associated with less apathy. Longitudinal studies are needed to evaluate a potential SSRI-induced apathy syndrome in PD. (The Journal of Neuropsychiatry and Clinical Neurosciences 2012; 24:326-330)

• 出版日期2012