科研之友
微信
新浪微博
Facebook
分享链接
摘要
Heterotrimeric G-proteins modulate many processes essential for embryonic development including cellular proliferation, migration, differentiation, and survival. Although most research has focused on identifying the roles of the various alpha subtypes, there is growing recognition that similarly divergent beta gamma dimers also regulate these processes. In this paper, we show that targeted disruption of the mouse Gng5 gene encoding the gamma(5) subtype produces embryonic lethality associated with severe head and heart defects. Collectively, these results add to a growing body of data that identify critical roles for the gamma subunits in directing the assembly of functionally distinct G-alpha beta gamma trimers that are responsible for regulating diverse biological processes. Specifically, the finding that loss of the G-gamma(5) subtype is associated with a reduced number of cardiac precursor cells not only provides a causal basis for the mouse phenotype but also raises the possibility that G-beta gamma(5) dependent signaling contributes to the pathogenesis of human congenital heart problems.
- 出版日期2014-3-5
