A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries

作者：Vannini Alessandro^*

来源：Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 2013, 1829(3-4): 258-264.

DOI：10.1016/j.bbagrm.2012.09.009

• Eukaryotic transcription
• RNA polymerase I
• RNA polymerase III
• rRNAs
• tRNAs
• Structural biology

RNA polymerase I and III are responsible for the bulk of nuclear transcription in actively growing cells and their activity impacts the cellular biosynthetic capacity. As a consequence, RNA polymerase I and III deregulation has been directly linked to cancer development. The complexity of RNA polymerase I and III transcription apparatuses has hampered their structural characterization. However, in the last decade tremendous progresses have been made, providing insights into the molecular and functional architecture of these multi-subunit transcriptional machineries. Here we summarize the available structural data on RNA polymerase I and III, including specific transcription factors and global regulators. Despite the overall scarcity of detailed structural data, the recent advances in the structural biology of RNA polymerase land III represent the first step towards a comprehensive understanding of the molecular mechanism underlying RNA polymerase I and III transcription. This article is part of a Special Issue entitled: Transcription by Odd Pals.

• 出版日期2013-4