A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori

作者：Tanaka Hiromitsu; Ishibashi Jun; Fujita Kosuke; Nakajima Yoshiro; Sagisaka Aki; Tomimoto Kazuya; Suzuki Noriko; Yoshiyama Mikio; Kaneko Yoichi; Iwasaki Takashi; Sunagawa Tomoya; Yamaji Kayoko; Asaoka Ai; Mita Kazuei; Yamakawa Minoru^*

来源：Insect Biochemistry and Molecular Biology, 2008, 38(12): 1087-1110.

DOI：10.1016/j.ibmb.2008.09.001

• Insect immunity
• Comparative genomics
• Gene family
• Signaling pathways
• Gene evolution
• Gene expression

A genome-wide analysis of innate immunity-related genes and gene families was conducted using the silkworm, Bombyx mod. We identified orthologs for a large number of genes involved in insect immunity that have been reported from Drosophila melanogaster (Diptera), Anopheles gambiae (Diptera), Apis mellifera (Hymenoptera) and Tribolium castaneum (Coleoptera). B. mod has a unique recognition gene and antimicrobial peptide genes that are not present in the Drosophila, Anopheles, Apis and Tribolium genomes, suggesting a lineage-specific gene evolution for lepidopteran insects. The comparative analysis of the insect immune repertoires indicated a dynamic and flexible gene expansion in recognition, modulation and effector mechanisms due to different selection pressures. Differential gene regulation by different bacterial species was found in PGRP and Serpin genes, suggesting that Bombyx has a highly selective gene regulation system depending on bacterial species.

• 出版日期2008-12