HtrA2/Omi is Involved in 6-OHDA-Induced Endoplasmic Reticulum Stress in SH-SY5Y Cells

作者：Luo, Feifei; Wei, Lei; Sun, Congcong; Chen, Xiaowu; Wang, Tan; Li, Yi; Liu, ZhuoLin; Chen, Zhibin; Xu, Pingyi^*

来源：Journal of Molecular Neuroscience, 2012, 47(1): 120-127.

DOI：10.1007/s12031-011-9694-0

• HtrA2
• Endoplasmic reticulum (ER) stress
• Parkinson's disease

Endoplasmic reticulum (ER) stress has been shown to be associated with the pathogenesis of neurodegenerative disorders including Parkinson's disease (PD). HtrA2/Omi, from its participation in protein quality control, is involved in ER stress. However, little is known about the relationship between HtrA2/Omi and ER stress in PD. Here, we explored the association of HtrA2/Omi and ER stress in a cell model of PD and found that the expression level of HtrA2/Omi decreased with ER stress induction in 6-OHDA-treated SH-SY5Y cells. Furthermore, silencing endogenous expression of HtrA2/Omi with siRNA resulted in aggregated ER stress and cell death. Taken together, our results show that HtrA2/Omi may exert a protective function in 6-OHDA-induced cell death by regulating ER stress-related proteins. This research offers some clues as why mutations in HtrA2/Omi lead to higher susceptibility in some PD patients.

• 出版日期2012-5
• 单位海南医学院; 重庆医科大学; 中山大学