Sialic acid tissue distribution and influenza virus tropism

作者：Kumlin Urban^*; Olofsson Sigvard; Dimock Ken; Arnberg Niklas

来源：Influenza and Other Respiratory Viruses, 2008, 2(5): 147-154.

DOI：10.1111/j.1750-2659.2008.00051.x

• eye
• influenza
• receptor
• sialic acid
• tropism

Avian influenza A viruses exhibit a strong preference for using alpha 2,3-linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for a2,3-linked sialic acid.

• 出版日期2008-9