The effect of milk polar lipids separated from butter serum on the lipid levels in the liver and the plasma of obese-model mouse (KK-A(y))

作者：Watanabe Shiomi; Takahashi Tomoki; Tanaka Leo; Haruta Yuko; Shiota Makoto; Hosokawa Masashi; Miyashita Kazuo^*

来源：Journal of Functional Foods, 2011, 3(4): 313-320.

DOI：10.1016/j.jff.2011.06.002

• Milk polar lipids
• Sphingomyelin
• Ceramide
• Lipid metabolism
• SCD1

The effect of lipid concentrated-butter serum (LC-BS) on the plasma and hepatic cholesterol and triacylglycerol levels of obese-model mouse (KK-A(Y)) was evaluated. The same analysis was done on the main lipid fractions from LC-BS, namely, ceramide rich fraction (Ceramide-fr), phosphatidylethanolamine (PE) rich fraction (PE-fr), and sphingomyelin (SPM) rich fraction (SPM-fr). Plasma cholesterol of mice fed LC-BS and Ceramide-fr was significantly (P < 0.05) lower than that of the control. Hepatic total cholesterol and triacylglycerol levels was also reduced significantly by Ceramide-fr feeding (P < 0.05). Although there was no significant difference in the fatty acid composition of all dietary lipids, significant decrease (P < 0.05) in content of 18:1n-9 was found in the liver lipids of the mice fed Ceramide-fr containing diet. The level of 16:1n-7 and 18:1n-7 was also reduced by Ceramide-fr feeding. This result suggests the down-regulation of stearoyl-CoA desaturase-1 (SCD1) by milk ceramides, which would be related to the decrease in triacylglycerol and cholesterol levels in the liver and in the plasma.

• 出版日期2011-10