A FACILE SYNTHESIS OF 2-ARYLTHIOCHROMAN-4-ONES BY THE REACTION OF 3-ARYL-1-(2-HALOPHENYL)PROP-2-EN-1-ONES WITH SODIUM HYDROGENSULFIDE

作者：Kobayashi Kazuhiro^*; Kobayashi Akihiro; Tanmatsu Miyuki

来源：Heterocycles, 2012, 85(4): 919-925.

DOI：10.3987/COM-12-12435

• Thiochroman-4-one
• Thioflavanone
• Chalcone
• Sodium Hydrogensulfide
• Intramolecular Conjugate Addition

An efficient two-step procedure for the preparation of 2-arylthiochroman-4-ones has been developed. Thus, 3-aryl-1-(2-halophenyl)prop-2-en-1-ones, prepared by the condensation between 1-(2-halophenyl)ethanones and aromatic aldehydes in ethanol at room temperature, were treated with sodium hydrogensulfide in DMF at 80 degrees C to give 2-arylthiochroman-4-ones in good overall yields.

• 出版日期2012-4-1