Modulation of calcium signalling by mitochondria

作者：Walsh Ciara; Barrow Stephanie; Voronina Svetlana; Chvanov Michael; Petersen Ole H; Tepikin Alexei^*

来源：Biochimica et Biophysica Acta-Bioenergetics, 2009, 1787(11): 1374-1382.

DOI：10.1016/j.bbabio.2009.01.007

• Calcium signalling
• ATP
• ROS
• IP3 receptor
• Ryanodine receptor
• Store-operated Ca(2+) entry

In this review we will attempt to summarise the complex and sometimes contradictory effects that mitochondria have on different forms of calcium signalling. Mitochondria can influence Ca(2+) signalling indirectly by changing the concentration of ATP, NAD(P)H, pyruvate and reactive oxygen species - which in turn modulate components of the Ca(2+) signalling machinery i.e. buffering, release from internal stores, influx from the extracellular solution, uptake into cellular organelles and extrusion by plasma membrane Ca(2+) pumps. Mitochondria can directly influence the calcium concentration in the cytosol of the cell by importing Ca(2+) via the mitochondrial Ca(2+) uniporter or transporting Ca(2+) from the interior of the organelle into the cytosol by means of Na(+)/Ca(2+) or H(+)/Ca(2+) exchangers. Considerable progress in understanding the relationship between Ca(2+) signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches.

• 出版日期2009-11