Different etiologies and prognoses of optic neuritis in demyelinating diseases

作者：Akaishi Tetsuya; Nakashima Ichiro^*; Takeshita Takayuki; Kaneko Kimihiko; Mugikura Shunji; Sato Douglas Kazutoshi; Takahashi Toshiyuki; Nakazawa Toru; Aoki Masashi; Fujihara Kazuo

来源：Journal of Neuroimmunology, 2016, 299: 152-157.

DOI：10.1016/j.jneuroim.2016.09.007

• Multiple sclerosis
• Neuromyelitis optica spectrum disorder
• Anti-MOG autoantibody
• Optic neuritis
• Optic MRI
• Visual prognosis

We compared the clinical features of optic neuritis (ON) that are frequently observed in various central nervous system demyelinating diseases, including multiple sclerosis (MS), anti-aquaporin 4 (AQP4) antibody- and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody-related diseases. Almost all the AQP4-ON patients were female, whereas half of the MOG-ON patients were male. The ON-onset age was younger in MS-ON and was older in AQP4-ON. The ON-lesion detected using optic MRI in the acute phase was longer in MOG-ON and showed severe swelling and twisting. The worst visual acuity was similar between the diseases; however, the final visual acuity was significantly worse in AQP4-ON.

• 出版日期2016-10-15