mTOR inhibitor rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice

作者：Hou, Guiqin; Zhang, Qi; Wang, Lili; Liu, Mingyue; Wang, Jianren; Xue, Lexun^*

来源：Cancer Letters, 2010, 290(2): 248-254.

DOI：10.1016/j.canlet.2009.09.015

• Apoptosis
• Esophageal squamous cell carcinoma (ESCC)
• mTOR
• Rapamycin
• Signaling pathway

Accumulating evidences have demonstrated that mTOR pathway has a central role not only in cell growth but also in invasion and metastasis of cancers. Here we reported that rapamycin or cisplatin alone inhibited significantly the tumor growth and their combination had the strongest anticancer effect on transplantable tumor growth of human ESCC cell line EC9706 in nude mice. Furthermore, western blots, RT-PCR and TUNEL assay revealed that rapamycin specifically blocked mTOR pathway and induced apoptosis of ESCC cells in vivo. These findings indicate a rationale for using mTOR inhibitors as a mechanism-based therapeutic approach to patients with ESCC.

• 出版日期2010-4-28
• 单位河南省人民医院; 郑州大学; 河南中医药大学