科研之友
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摘要
The propagation of information inside cells is achieved in nature by small diffusible molecules. Many of these secondary messengers are highly charged species derived from myo-inositol. The diphosphoinositol polyphosphates (X-PP-myo-InsP(5)) represent a novel group of secondary messengers that regulate various important biological processes. Depending on the phosphorylation pattern, these molecules can occur in symmetric or nonsymmetric forms. In a recent study, we have shown the potential of C-2 symmetric phosphoramidites as reagents for desymmetrizing myo-inositol and for obtaining all four possible nonsymmetric X-PP-myo-InsP(5) stereoisomers in enantiomerically pure form. These results and their potential implications for the design of tools for chemical biology are discussed.
- 出版日期2014-7
