Apolipoproteins A-I and B As Components of Metabolic Syndrome with Respect to Diabetes Status: A Factor Analysis

作者：Esteghamati Alireza; Zandieh Ali; Esteghamati Abdoulreza; Sadaghiani Mohammad Salehi; Zandieh Basira; Rezaeitabar Elham; Nakhjavani Manouchehr

来源：Metabolic Syndrome and Related Disorders, 2012, 10(4): 280-285.

DOI：10.1089/met.2011.0149

Background: The aim of the current study was to elucidate the clustering pattern of metabolic syndrome components along with apolipoproteins (Apo) A-I and B in diabetic and nondiabetic subjects. %26lt;br%26gt;Methods: Factor analysis of conventional variables of metabolic syndrome [i.e., waist circumference, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and systolic blood pressure (SBP)] with or without addition of Apo A-I and B was performed on 567 and 327 diabetic and nondiabetic subjects, respectively. Thereafter, analyses were repeated after substitution of TG and HDL-C by the TG-to-HDL-C ratio (TG/HDL-C). %26lt;br%26gt;Results: Regarding conventional variables of metabolic syndrome, one or two underlying factors were identified, depending on whether lipid measures were entered as two distinct variables or as a composite measure. Apolipoproteins were consistent with a one-factor structure model of metabolic syndrome and did not change the loading pattern remarkably in nondiabetics. TG and HDL-C tended to cluster with Apo B and A-I, respectively, in different models. %26lt;br%26gt;Conclusion: The current study confirms that addition of Apo A-I and B is consistent with the one-factor model of metabolic syndrome and does not modify the loading pattern remarkably in nondiabetic subjects.

• 出版日期2012-8