Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos

作者：Meraz Rios Marco Antonio^*; Majluf Cruz Abraham; Santana Carla; Noris Gino; Camacho Mejorado Rafael; Acosta Saavedra Leonor C; Calderon Aranda Emma S; Hernandez Juarez Jesus; Magana Jonathan J; Gomez Rocio

来源：Biomed Research International, 2014, 2014: 697689.

DOI：10.1155/2014/697689

Objective. Venous thromboembolism (VTE) is amultifactorial disorder and, worldwide, the most important cause of morbidity and mortality. Genetic factors play a critical role in its aetiology. Microsatellites are the most important source of human genetic variation having more phenotypic effect than many single nucleotide polymorphisms. Hence, we evaluate a possible relationship between VTE and the genetic variants in von Willebrand factor, human alpha fibrinogen, and human thyroid peroxidase microsatellites to identify possible diagnostic markers. Methods. Genotypes were obtained from 177 patients with VTE and 531 nonrelated individuals using validated genotyping methods. The allelic frequencies were compared; Bayesian methods were used to correct population stratification to avoid spurious associations. Results. The vWA-18, TPOX-9, and TPOX-12 alleles were significantly associated with VTE. Moreover, subjects bearing the combination vWA-18/TPOX-12 loci exhibited doubled risk for VTE (95% CI = 1.023.64), whereas the combination vWA-18/TPOX-9 showed an OR = 10 (95% CI = 4.93-21.49). Conclusions. The vWA and TPOX microsatellites are good candidate biomarkers in venous thromboembolism diseases and could help to elucidate their origins. Additionally, these polymorphisms could become useful markers for genetic studies of VTE in the Mexican population; however, further studies should be done owing that this data only show preliminary evidence.

• 出版日期2014