Development of a palladium catalyzed addition of boronic acids to alkynyl esters: synthesis of trisubstituted olefins as single isomers

作者：Bush Alexander Graham; Jiang Jojo Liu; Payne Philippa R; Ogilvie William W^*

来源：Tetrahedron, 2009, 65(41): 8502-8506.

DOI：10.1016/j.tet.2009.08.029

Very small phosphine ligands allow access to single isomer trisubstituted olefins from alkynyl esters with complete control of both stereochemistry and regiochemistry. This method provides a convenient synthesis of single isomer trisubstituted olefins without requiring olefin templates.

• 出版日期2009-10-10