Association of biochemical markers with the severity of pre-eclampsia

作者：Maged Ahmed M^*; Aid Gamal; Bassiouny Nehal; Eldin Doaa S; Dahab Sherif; Ghamry Nevein K

来源：International Journal of Gynecology & Obstetrics, 2017, 136(2): 138-144.

DOI：10.1002/ijgo.12029

• Biochemical markers
• C-reactive protein
• Maternal complications
• Neonatal complications
• Severe pre-eclampsia

Objective: To assess the association between pre-eclampsia severity and biochemical and ultrasonography markers.
Methods: A retrospective study was undertaken of women with severe pre-eclampsia (group 1, n= 90), mild pre-eclampsia (group 2, n= 90), or a normal pregnancy (group 3, n= 90) who attended a hospital in Egypt in October 2013-April 2015. Associations between pre-eclampsia and biochemical, cardiotocography, and ultrasonography markers were investigated.
Results: There were significant differences between the groups in C- reactive protein (331.44 +/- 112.38, 251.43 +/- 59.05, and 23.81 +/- 16.19 nmol/L; P= 0.05 for all), platelet count (113.40 +/- 36.72, 172.93 +/- 57.60, and 212.68 +/- 70.00x109/L; P= 0.05 for group 1 comparisons), alanine transaminase (52.24 +/- 14.83, 38.34 +/- 13.12, and 23.11 +/- 6.92 U/L; P= 0.05 for group 1 comparisons), and serum uric acid (600.80 +/- 117.19, 481.83 +/- 118.97, and 243.89 +/- 53.54 mu mol/L; P= 0.050 for group 3 comparisons). Cardiotocography score was worse among women with severe pre-eclampsia than among those in the other two groups (P= 0.039 for both comparisons). Biophysical profile score and umbilical artery resistance index differed by group (P= 0.05 for all). Middle cerebral artery resistance index was lower among women with severe pre-eclampsia (P= 0.05).
Conclusion: The levels of C- - reactive protein, blood urea nitrogen, serum uric acid, and alanine transaminase, and the platelet count were linked with the presence and severity of pre-eclampsia.

• 出版日期2017-2