An update on PYRIN domain-containing pattern recognition receptors: from immunity to pathology

作者：Ratsimandresy Rojo A; Dorfleutner Andrea; Stehlik Christian^*

来源：Frontiers in Immunology, 2013, 4.

DOI：10.3389/fimmu.2013.00440

• PYRIN domain
• innate immunity
• pattern recognition receptor
• Nod-like receptor
• NLR
• AIM2-like receptor
• ALR
• inflammasome

Cytosolic pattern recognition receptors (PRRs) sense a wide range of endogenous dangerassociated molecular patterns as well as exogenous pathogen-associated molecular patterns. In particular, Nod-like receptors containing a pyrin domain (PYD), called NLRPs, and AIM2-like receptors (ALRs) have been shown to play a critical role in host defense by facilitating clearance of pathogens and maintaining a healthy gut microflora. NLRPs and ALRs both encode a PYD, which is crucial for relaying signals that result in an efficient innate immune response through activation of several key innate immune signaling pathways. However, mutations in these PRRs have been linked to the development of autoinflammatory and autoimmune diseases. In addition, they have been implicated in metabolic diseases. In this review, we summarize the function of PYD-containing NLRPs and ALRs and address their contribution to innate immunity, host defense, and immune-linked diseases.

• 出版日期2013
• 单位西北大学