A 356-kb sequence of the subtelomeric part of the MHC class I region

作者：Hampe A^*; Coriton O; Andrieux N; Carn G; Lepourcelet M; Mottier S; Dreano S; Gatius MT; Hitte C; Soriano N; Galibert F

来源：DNA Sequence, 1999, 10(4-5): 263-+.

• human
• genomic sequence
• MHC Class I
• sequence analogy
• bioinformatic
• repetitive DNA

The subtelomeric part of the MHC Class I region contains 11 of the 21 genes described on chromosome 6 at position 6p21.3. The general organization of those and other genes resident in the region was revealed by determining a 356,376 bp sequence. Potential exons for new genes were identified by computer analysis and a large number of ESTs were selected by testing the sequence by the BLAST algorithm against the Gen-Bank nonredundant and EST databases. Most of the ESTs are clustered in two regions. In contrast, the whole HLA-gene region is crammed with LINE and SINE repeats, fragments of genes and microsatellites, which tends to hinder the identification of new genes.

• 出版日期1999