Association Between NFKB1-94 Insertion/Deletion ATTG Polymorphism and Risk of Intracranial Aneurysm

作者：Sima, Xiutian; Xu, Jianguo; Li, Jin; You, Chao^*

来源：Genetic Testing and Molecular Biomarkers, 2013, 17(8): 620-624.

DOI：10.1089/gtmb.2013.0110

• NF-KAPPA-B
• CEREBRAL ANEURYSMS
• PROMOTER POLYMORPHISM
• SUBARACHNOID HEMORRHAGE
• INFLAMMATION
• PROGRESSION
• GENE
• EXPRESSION
• RUPTURE
• STRESS

Objective: Growing evidence indicates that vascular inflammation is a common phenomenon in the pathogenesis of intracranial aneurysms (IAs). Nuclear factor kappa B is a key molecule that is involved in the vascular inflammation of IA. We hypothesized that an insertion/deletion (ins/del) ATTG polymorphism located between two putative key promoter regulatory elements in the NFKB1 gene may be related to the risk of IA. Methods: We performed a case-control study, including 164 patients with IA and 525 healthy controls in a Chinese population using a polymerase chain reaction-polyacrylamide gel electrophoresis assay. Results: A significantly decreased risk of IA was observed in the ATTG1/ATTG2 and ATTG2/ATTG2 genotypes compared with the ATTG1/ATTG1 genotype (ATTG1/ATTG2 vs. ATTG1/ATTG1: odds ratio [OR] = 0.58, 95% confidence interval [95% CI] = 0.39-0.87, p = 0.007; ATTG2/ATTG2 vs. ATTG1/ATTG1: OR = 0.12, 95% CI = 0.06-0.23, p < 0.001), and also the ATTG2 allele (ATTG2 vs. ATTG1: OR = 0.41, 95% CI = 0.32-0.54, p < 0.001). Conclusion: These findings suggest that the NFKB1 -94ins/del ATTG polymorphism may contribute to the risk of IA.

• 出版日期2013-8
• 单位四川大学