A randomized phase II trial of S-1-oxaliplatin versus capecitabine-oxaliplatin in advanced gastric cancer

作者：Kim Gun Min; Jeung Hei Cheul; Rha Sun Young; Kim Hyo Song; Jung Inkyung; Nam Byung Ho; Lee Kyung Hee; Chung Hyun Cheol^*

来源：European Journal of Cancer, 2012, 48(4): 518-526.

DOI：10.1016/j.ejca.2011.12.017

• S-1
• Capecitabine
• Gastric cancer
• Oxaliplatin

Purpose: S-1 or capecitabine plus oxaliplatin are considered active and tolerable in gastric cancer patients. We conducted a randomized phase II trial in gastric cancer patients to compare the activity and safety of these combinations. %26lt;br%26gt;Methods: The patients received S-1 at 80 mg/m(2) for 14 days, followed by a 7-day rest period within a 3-week schedule in the S-1/oxaliplatin (SOX) arm, and capecitabine at 2000 mg/m(2) for 14 days, followed by a 7-day rest period within a 3-week schedule in the capecitabine/oxaliplatin (CAPOX) arm. Oxaliplatin 130 mg/m(2) was administered every 3 weeks in both arms. %26lt;br%26gt;Results: One hundred twenty-nine patients were randomly assigned to SOX (N = 65) or CAPOX (N = 64). The median time to progression and the overall survival were 6.2 and 12.4 months with SOX, respectively; and 7.2 and 13.3 months with CAPOX, respectively. The overall response rates were 40% and 44% for SOX and CAPOX, respectively. The most frequent grade 3 or 4 toxicities were thrombocytopenia (15.4%) for SOX and neutropenia (18.8%) for CAPOX. The median time to 10% deteriorations in global health scores was similar in both arms (SOX, 4.3 months, CAPOX, 4.9 months). %26lt;br%26gt;Conclusion: Both the SOX and CAPOX regimens were equally active and well tolerated in advanced gastric cancer patients.

• 出版日期2012-3