Dipeptidyl Peptidase IV and Incident Diabetes The Atherosclerosis Risk in Communities (ARIC) study

作者：Luft Vivian C; Schmidt Maria Ines; Pankow James S; Hoogeveen Ron C; Couper David; Heiss Gerardo; Duncan Bruce B^*

来源：Diabetes Care, 2010, 33(5): 1109-1111.

DOI：10.2337/dc09-1996

OBJECTIVE - Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes.
RESEARCH DESIGN AND METHODS - Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over similar to 9 years within the Atherosclerosis Risk in Communities study.
RESULTS - In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors.
CONCLUSIONS - Fasting DPP-IV levels do not appear to predict incident diabetes.

• 出版日期2010-5