Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment

作者：Ramakers I H G B^*; Verhey F R J; Scheltens P; Hampel H; Soininen H; Aalten P; Rikkert M Olde; Verbeek M M; Spiru L; Blennow K; Trojanowski J Q; Shaw L M; Visser P J

来源：Psychological Medicine, 2013, 43(5): 911-920.

DOI：10.1017/S0033291712001870

• Alzheimer%26apos
• s disease
• anxiety
• apathy
• biomarkers
• cerebrospinal fluid
• depression
• mild cognitive impairment
• neuropsychiatric symptoms

Background. Anxiety, apathy and depression are common in subjects with mild cognitive impairment (MCI) and may herald Alzheimer%26apos;s disease (AD). We investigated whether these symptoms correlated with cerebrospinal fluid (CSF) markers for AD in subjects with MCI. %26lt;br%26gt;Method. Subjects with MCI (n = 268) were selected from the %26apos;Development of screening guidelines and criteria for pre-dementia Alzheimer%26apos;s disease%26apos; (DESCRIPA) and Alzheimer%26apos;s Disease Neuroimaging Initiative (ADNI) studies. We measured amyloid beta((1-42)) protein (A beta 42) and total tau (t-tau) in CSF. Neuropsychiatric symptoms were measured with the Neuropsychiatric Inventory. %26lt;br%26gt;Results. Depressive symptoms were reported by 55 subjects (21%), anxiety by 35 subjects (13%) and apathy by 49 subjects (18 %). The presence of anxiety was associated with abnormal CSF A beta 42 [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.6-3.3] and t-tau (OR 2.6, 95% CI 1.9-3.6) concentrations and with the combination of abnormal concentrations of both A beta 42 and t-tau (OR 3.1, 95% CI 2.0-4.7). The presence of agitation and irritability was associated with abnormal concentrations of A beta 42 (agitation: OR 1.6, 95% CI 1.1-2.3; irritability: OR 2.2, 95% CI 1.5-3.3). Symptoms of depression and apathy were not related to any of the CSF markers. %26lt;br%26gt;Conclusions. In subjects with MCI, symptoms of anxiety, agitation and irritability may reflect underlying AD pathology, whereas symptoms of depression and apathy do not.

• 出版日期2013-5