Aptamer and graphene-based electrochemical biosensor for dopamine determination with high sensitivity and selectivity

作者：Jiao, Luyang^*; Lu, Guangjian; Zhang, Chunxiao; Yuan, Yan; Wang, Junxiang; Zhang, Qunmei; Li, Pingfa

来源：Micro & Nano Letters, 2013, 8(12): 903-905.

DOI：10.1049/mnl.2013.0626

• biosensors
• diseases
• electrochemical sensors
• molecular biophysics
• molecular configurations
• nanostructured materials
• neurophysiology
• RNA
• sensitivity
• sheet materials
• graphene
• nanosensors
• C
• graphene nanosheets
• electronic properties
• RNA aptamer
• specihc recognition
• cost-effective electrochemical method
• convenient electrochemical method
• dopamine detection
• neurodegenerative diseases
• psychiatric diseases
• dopamine metabolism
• neurotransmitter
• dopamine determination

Dopamine is a kind of neurotransmitter. The abnormalities in dopamine metabolism may lead to various psychiatric and neurodegenerative diseases. Thus, fast and accurate detection of dopamine is urgently needed. Presented in this Letter is a convenient and cost-effective electrochemical method for the detection of dopamine based on aptamer and graphene. The specific recognition between dopamine and the RNA aptamer allows high selectivity, and the excellent electronic properties of graphene nanosheets ensure the high sensitivity of this biosensor.

• 出版日期2013-12
• 单位新乡医学院