High IL-10 production by aged AIDS patients is related to high frequency of Tr-1 phenotype and low in vitro viral replication

作者：Andrade Regis M; Hygino Joana; Kasahara Taissa M; Vieira Morgana M; Xavier Luciana F; Blanco Bernardo; Damasco Paulo V; Silva Rodrigo M; Lima Dirce B; Oliveira Ariane L; Lemos Alberto S; Andrade Arnaldo F B; Bento Cleonice A M^*

来源：Clinical Immunology, 2012, 145(1): 31-43.

DOI：10.1016/j.clim.2012.08.002

• HIV
• Aging
• Anti-retroviral therapy
• IL-10
• FoxP3
• CD152

This work aims to elucidate the effects of age and HIV-1 infection on the frequency and function of T cell subsets in response to HIV-specific and non-specific stimuli. As compared with the younger AIDS group, the frequencies of naive and central memory T cells were significantly lower in aged AIDS patients. Although there was also a dramatic loss of classical CD4(+)FoxP3(+)CD25(+)Treg cells in this patient group, high frequencies of IL-10-producing CD4(+)FoxP3(-) T cells were observed. In our system, the increased production of IL-10 in aged AIDS patients was mainly derived from Env-specific CD4(+)FoxP3(-)CD152(+) T cells. Interestingly, while the blockade of IL-10 activity by monoclonal antibody clearly enhanced the release of IL-6 and IL-1 beta by Env-stimulated PBMC cultures from aged AIDS patients, this monoclonal antibody enhanced in vitro HIV-1-replication. In conclusion, HIV infection and aging undoubtedly contribute synergistically to a complex immune dysfunction in T cell compartment of HAART-treated older HIV-infected individuals.

• 出版日期2012-10