Alzheimer and platelets: Low-density platelet populations reveal increased serotonin content in Alzheimer type dementia

作者：Milovanovic Micha^*; Eriksson Kristoffer; Winblad Bengt; Nilsson Staffan; Lindahl Tomas L; Post Claes; Jaremo Petter

来源：Clinical Biochemistry, 2014, 47(15): 51-53.

DOI：10.1016/j.clinbiochem.2014.07.007

• Alzheimer's disease
• Fibrinogen
• Platelets
• Platelet activity
• Platelet density
• Platelet heterogeneity
• Serotonin

Introduction: Alzheimer's disease (AD) is a progressive form of dementia characterized by an increase in the toxic substance beta-amyloid in the brain. Platelets display a substantial heterogeneity with respect to density. They further contain a substantial amount of beta-amyloid precursor protein. Platelets take up and store serotonin (5-HT) that plays an important role in the pathogenesis of severe depression. The current study aims to investigate platelet serotonin content in different platelet density populations.
Material and methods: The study involved 8 patients (age 70 +/- 8 (SD) years) (3 females/5 males) with moderate AD. 6 healthy elderly subjects (age 66 +/- 9 (SD) years) (3 females/3 males) served as controls. The platelet population was divided into 17 subpopulations according to density, using a linear Percoll (TM) gradient. Platelets were counted in all fractions. After cell lysis an ELISA technique was employed to determine the 5-HT content in each platelet subfraction.
Results: The two study groups did not differ significantly regarding platelet distribution in the gradients, but AD sufferers have a significantly higher 5-HT content (p < 0.05) in the lighter platelet populations.
Discussion: AD-type dementia proved to be associated with lighter platelets containing more 5-HT. It is possible that platelets from AD patients release less 5-HT. It is speculated that AD synapses are affected in a manner comparable to platelets, which could explain why 5-HT reuptake inhibitors are less effective in AD dementia.

• 出版日期2014-10