科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background. Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin disease characterized by abscesses, fistulating sinus tracts, and scarring. The exact pathogenesis of this disease remains unclear. We present our experience with HS and a possible cause of the disease and offer a surgical and clinical treatment that allows for disease resolution. %26lt;br%26gt;Methods. We studied 12 patients who presented with axillary and perineal fistulas and underwent surgical excision.(repaired by skin grafts or healing by secondary intention) or localized treatments%26apos; followed by diet modification. All patients were found to have a specific immunology IgG reaction to brewer%26apos;s yeast and wheat and were put on a controlled brewer%26apos;s yeast free diet for 12 months and followed monthly. %26lt;br%26gt;Results. The diet demonstrated immediate stabilization of their clinical symptoms, and the skin lesions regressed over the 12-month treatment period. Similarly, all the patients demonstrated an immediate recurrence of skin lesions following accidental or voluntary consumption of beer or other foods containing brewer%26apos;s yeast or wheat. The patients also demonstrated a return of their quality Of life and activities, including the reestablishment of sexual activity in the patients with inguinal and perigenital lesions. %26lt;br%26gt;Conclusion. The results of the investigation suggested that the patients had severe reactions to brewer%26apos;s yeast. Surgery followed by the elimination of. the foods containing or made with the yeast resulted in a rapid stabilization of the dermatologic manifestation and a slow, but complete, regression of the skin lesions within a year. Despite the small number of patients in our study, our study could provide the basis for extensive and multicentric studies in order to better investigate this disabling and rare disease.
- 出版日期2013-11
