科研之友
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摘要
Background: Breast cancer is a heterogeneous disease consisting of different subtypes. Trichorhinophalangeal syndrome type 1 (TRPS1) gene, a GATA-type transcription factor, has been found to be highly expressed in breast cancer. Epithelial-to-mesenchymal transition (EMT) is known to play an important role in tumour invasion and metastasis. Our objective was to elucidate the different roles and clinical relevance of TRPS1 in different estrogen receptor (ER) expression subtypes of breast cancer. Methods: An immunohistochemical study was performed. The correlation between clinicopathological features and other biomarker profiles were analysed statistically. Result: TRPS1 expression was correlated with the patients' age (P = 0.017). It was positively related with ER alpha (P < 0.001), progesterone receptor (PR) (P < 0.001) and ER beta (P = 0.001) status, but negatively associated with Ki67 (P = 0.002) and HER2 (P = 0.025) status. In ER alpha-positive breast cancer, TRPS1 expression was positively associated with the expression of E-cadherin (P < 0.001), beta-catenin(P = 0.001), ER beta (P = 0.03), and p53 (P = 0.002) status, while in ER alpha-negative breast cancer, TRPS1 expression was correlated with slug (P = 0.004), vimentin (P = 0.003), smooth muscle actin (SMA) (P = 0.031), and IMP3 (P = 0.005) expression. Conclusions: Based on our findings, we conclude that TRPS1 is positively associated with E-cadherin and beta-catenin status in ERa-positive breast cancer cells, while it is also significantly associated with mesenchymal markers of EMT in ERa-negative breast cancer cells. TRPS1 can be a prognostic marker depending on the type of breast cancer. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8686515681264281
- 出版日期2014-6-16
- 单位山东大学
