科研之友
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摘要
A novel and efficient method has been developed for the direct construction of imino-pyrrolidine-thione scaffold via the coupling of isocyanides, heterocyclic thiols, and gem-dicyano olefins. Smiles rearrangement followed by intramolecular cyclization leads directly to formation of the core structure. A water-acceleration effect is observed, promoting most of the reactions to go to completion within a short reaction time.
- 出版日期2010-12
- 单位苏州大学
