4,6-DIMETHYLPYRIDINE-2,3-DICARBONITRILE AND ITS REACTION WITH N-ACYLHYDRAZINES

作者：Rudenko I V; Kucherak A A; Tolmachev A A; Hordiyenko O V^*

来源：Chemistry of Heterocyclic Compounds, 2011, 47(8): 964-969.

• N '-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene)carbohydrazid es
• N '-(5-amino-2,4-dimethyl-7H-pyrrolo[3,4-b]pyridin-7-ylidene)carbohydrazid es
• N-acylhydrazones
• 4,6-dimethylpyridine-2,3-dicarbonitrile
• N ',N ''-(2,4-dimethyl-5H-pyrrolo[3,4-b]pyridine-5,7-diylidene)dicarbohydrazid es
• nucleophilic substitution of hydrogen
• cyanation

An efficient method has been developed for the synthesis of 4,6-dimethylpyridine-2,3-dicarbonitrile. A study was carried out on the reaction of this compound with N-acylhydrazines to give two structural isomers, namely, N'-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene)carbohydrazides and N'-(5-amino-2,4-dimethyl-7H-pyrrolo[3,4-b]pyridin-7-ylidene)carbohydrazides as well as disubstituted N',N ''-(2,4-dimethyl-5H-pyrrolo[3,4-b]pyridine-5,7-diylidene)dicarbohydrazides.

• 出版日期2011-10