科研之友
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摘要
A discovery that the inexpensive Br-2 can serve as a potent Lewis acid catalyst for bis(2-hydroxy-1-naphthyl)methanes synthesis is presented. Under the catalysis of Br-2 at room temperature, naphthols reacted smoothly with various aldehydes with high efficiency and broad substrate scope. This reaction used to require highly acidic conditions and/or high temperature and/or pressure, and sometimes featured poor yields. Moreover, theoretical calculations suggested that Br-2 is a potent Lewis acid to activate the carbonyl group, yet it was not the primary cause for the remarkable activity of Br-2 in the current communication.
