Genetic variation of vascular endothelial growth factor pathway does not correlate with the severity of retinopathy of prematurity

作者：Kusuda T; Hikino S; Ohga S^*; Kinjo T; Ochiai M; Takahata Y; Tokunaga S; Ihara K; Hata Y; Hara T

来源：Journal of Perinatology, 2011, 31(4): 246-250.

DOI：10.1038/jp.2010.111

• vascular endothelial growth factor
• retinopathy of prematurity
• neovascularization
• preterm infants

Objective: The aim of this study was to assess the genetic effects of the vascular endothelial growth factor (VEGF) pathway on retinopathy of prematurity (ROP).
Study Design: A prospective study from a tertiary center that enrolled 204 Japanese infants (<35 weeks of gestational age (GA)) having no anomalies. ROP developed in 127, but not in 77 infants. The relative severity was defined as non-severe, moderate and severe ROP for GA, based on the staging criteria. VEGF (g.-634G>C, g.+13553C>T) and VEGF-receptor (KDR g.+4422(AC) 11 to 14, Flt-1 c. + 6724(TG)13 to 23) gene polymorphisms and clinical variables were assessed by uni/multivariate analyses.
Result: The frequency of polymorphisms did not differ between ROP and non-ROP patients. The TT genotype of g. + 13553 showed a higher odds ratio for non-severe ROP than CC genotype (P = 0.006). Multivariate analyses indicated that low birth weight, blood transfusion and respiratory distress syndrome, but not polymorphisms, were the risk factors of advanced ROP (>= stage 3).
Conclusion: A genotype of the VEGF pathway weakly affects the severity of ROP compared with other clinical factors. Journal of Perinatology (2011) 31, 246-250; doi: 10.1038/jp.2010.111; published online 12 August 2010

• 出版日期2011-4