Size Matters: Side Chain Length Affects SH2 Substrate Binding

作者:Becker Christian F W*
来源:Chemistry & Biology, 2010, 17(3): 211-212.
DOI:10.1016/j.chembiol.2010.03.001

摘要

The incorporation of lysine analogs in Src Homology 2 (SH2) domain variants by Virdee et al. (2010) reveals the length-dependent contribution of a single amino acid side chain in recognition of phosphotyrosine-containing substrate peptides and a change in specificity with shorter side chains.

  • 出版日期2010-3-26

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