Asymmetric hydrogenation of aromatic ketones with MeO-PEG-supported BIPHEP/DPEN ruthenium catalysts

作者：Chai, Li-Ting; Wang, Wei-Wei; Wang, Quan-Rui^*; Tao, Feng-Gang

来源：Journal of Molecular Catalysis A: Chemical , 2007, 270(1-2): 83-88.

DOI：10.1016/j.molcata.2007.01.042

• MeO-PEG
• supported catalyst
• asymmetric hydrogenation
• aryl ketones

A soluble polymer (MeO-PEG) supported biphenylbisphosphine (BIPHEP)-Ru/chiral diamine (1,2-diphenylethylenediamine) complex, in which the polymer is attached to the two phenyl rings of BIPHEP ligand, has been prepared, and shown to be highly active with good enantioselectivity for the catalyzed asymmetric hydrogenation of unfunctionalized aromatic ketones. The derived chiral ruthenium complex 5 proved to be stable in air allowing facile catalyst recycling. Especially for 4 '-tert-butyl-acetophenone and l-acetonaphthone, excellent ee values up to 96.5% and 95.9% have been obtained which are comparable to or even higher than the enantioselectivity achieved with 2,2 '-bis(diphenylphosphino)-1,1 '-binaphthyl-Ru-DPEN catalyst under similar conditions.

• 出版日期2007-6-1
• 单位复旦大学