ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI

作者：Yiannakas Marios C^*; Tozer Daniel J; Schmierer Klaus; Chard Declan T; Anderson Valerie M; Altmann Daniel R; Miller David H; Wheeler Kingshott Claudia A M

来源：Multiple Sclerosis, 2013, 19(6): 732-741.

DOI：10.1177/1352458512462074

• ADIMA
• lesion volume
• relapsing-remitting multiple sclerosis
• magnetic resonance imaging
• white matter lesions
• MRI methods
• brain lesion sub-classification

Background: There are modest correlations between multiple sclerosis (MS) disability and white matter lesion (WML) volumes, as measured by T2-weighted (T2w) magnetic resonance imaging (MRI) scans (T2-WML). This may partly reflect pathological heterogeneity in WMLs, which is not apparent on T2w scans. %26lt;br%26gt;Objective: To determine if ADvanced IMage Algebra (ADIMA), a novel MRI post-processing method, can reveal WML heterogeneity from proton-density weighted (PDw) and T2w images. %26lt;br%26gt;Methods: We obtained conventional PDw and T2w images from 10 patients with relapsing-remitting MS (RRMS) and ADIMA images were calculated from these. We classified all WML into bright (ADIMA-b) and dark (ADIMA-d) sub-regions, which were segmented. We obtained conventional T2-WML and T1-WML volumes for comparison, as well as the following quantitative magnetic resonance parameters: magnetisation transfer ratio (MTR), T1 and T2. Also, we assessed the reproducibility of the segmentation for ADIMA-b, ADIMA-d and T2-WML. %26lt;br%26gt;Results: Our study%26apos;s ADIMA-derived volumes correlated with conventional lesion volumes (p %26lt; 0.05). ADIMA-b exhibited higher T1 and T2, and lower MTR than the T2-WML (p %26lt; 0.001). Despite the similarity in T1 values between ADIMA-b and T1-WML, these regions were only partly overlapping with each other. ADIMA-d exhibited quantitative characteristics similar to T2-WML; however, they were only partly overlapping. Mean intra-and inter-observer coefficients of variation for ADIMA-b, ADIMA-d and T2-WML volumes were all %26lt; 6 % and %26lt; 10 %, respectively. %26lt;br%26gt;Conclusion: ADIMA enabled the simple classification of WML into two groups having different quantitative magnetic resonance properties, which can be reproducibly distinguished.

• 出版日期2013-5