Memory B cells in common variable immunodeficiency: Clinical associations and sex differences

作者：Sanchez Ramon Silvia; Radigan Lin; Yu Joyce E; Bard Susan; Cunningham Rundles Charlotte^*

来源：Clinical Immunology, 2008, 128(3): 314-321.

DOI：10.1016/j.clim.2008.02.013

• CVID
• IgM memory B cells
• switched memory B cells
• pneumococcal antibody
• sex differences
• IgG
• splenectomy

Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by impaired antibody responses, recurrent infections, inflammatory, autoimmune and malignancy- related conditions. We evaluated the relationship between memory B cell phenotype, sex, age at diagnosis, immunologic and clinical conditions in 105 CVID subjects from one medical center. Reduced numbers of switched memory B cells (cutoff <= 0.55% of B cells) were an independent risk factor of granulomas, autoimmune diseases and splenomegaly (p<0.001). Not previously noted, CVID females had significantly more switched memory cells (p=0.007) than mates. Splenectomized subjects did not have fewer IgM memory B cells and these numbers were not related to the development of lung disease, as previously proposed. Lower baseline serum IgG was an independent predictor of pneumonia (p=0.007) and severe infections (p=0.001). We conclude that outcomes in CVID depend on an interplay of factors including sex, numbers of switched memory B cells, and baseline serum IgG and IgA levels.

• 出版日期2008-9