Acid catalysed reaction of estrones with neopentyl glycol under forced conditions

作者:Oliveira Cristina; Morais Goreti Ribeiro; Imai Masao; Inohae Eiko; Yamamoto Chishou; Mataka Shuntaro; Thiemann Thies*
来源:Journal of Chemical Research, 2010, (3): 158-162.
DOI:10.3184/030823410X12678785299942

摘要

Upon reaction with an excess of 2,2-dimethylpropane-1,3-diol (neopentyl glycol) under acid catalysis, estrones form 17-O-[2', 2'-dimethyl-2'-(5 '', 5 ''-dimethyl-1 '', 3 ''-dioxanyl)ethyl] substituted estra-3,17 beta-diols. The reaction represents a formal reduction of a keto function under acidic conditions in the absence of a metal.

  • 出版日期2010-3